The RNAdvance Tissue system, for isolation of total RNA from mammalian samples, is based on Agencourt SPRI (Solid Phase Reversible Immobilization) paramagnetic bead nucleic acid purification technology. The system produces clean RNA with high recovery, in single-tube or 96-well formats, while eliminating organic solvents, vacuum filtration and centrifugation steps. Researchers can maximize the use of tissue samples without compromising RNA integrity. The process can be automated on the Beckman Coulter Biomek NX liquid handling workstation for a fully validated and supported walk-away solution. For microarray applications, the system can be used with Agencourt RNAClean technology for a complete solution for RNA purification and recovery.