SpectraMax M5 five-mode multi-detection microplate reader system has primary applications for fluorescence intensity, absorbance, luminescence, Time-Resolved Fluorescence (TRF) and Fluorescence Polarization (FP) assays. A triple-mode cuvette port and a single-read command capability are provided for experiments requiring multiple detection parameters. Users can choose wavelengths between 200 and 1000 nm. Standard microplates are used to read endpoint, kinetic, spectrum, multi-wavelength and well-area scanning. The system is well suited for ELISA, nucleic acid, protein quantitation, enzymatic, cell viability and proliferation assays. Kinase, reporter gene, FRET and other homogeneous and heterogeneous assays can also be run. When the instrument is integrated with the company’s SynchroMax ET plate handling robot, up to 320 plates can be run without interruption, with multiple assay parameters on each plate.