Ultra Evolution multifunctional detection platform adds fluorescence lifetime microplate measurements to the detection modes of the Tecan US Ultra family (which include absorbance, fluorescence intensity, fluorescence polarization, and luminescence). This instrument supports a wide range of routine applications used in target identification or lead discovery groups, assay development groups, high throughput screening facilities, secondary and confirmatory screening groups, and contract research/screening companies. FLT is not limited to molecular systems with small, labeled ligands and large receptors. Tecan US has shown that the fluorescent signal from compounds can be distinguished from that of the label, even when it is present in excess and fluoresces at the same or similar wavelength as the label. A choice of two laser excitation sources (red at 635 nm, blue at 440 nm) is offered with the fluorescence lifetime module. True bottom reading detection is available for cell-based assays, yet the instrument retains the "z" axis optimization feature used in top reading mode. A Multi-Check QC plate will also be offered with the system. It offers absorbance, fluorescence intensity and fluorescence polarization detection and accuracy checks, as well as a further plate transport positioning check function.