A collaboration of researchers found an unusual mutation has been found that is strongly linked to one such disease: a rare liver cancer that affects teens and young adults. The results suggest that the mutation plays a key role in the development of the disease, called fibrolamellar hepatocellular carcinoma, and may also underlie more common cancers as well.
Tau proteins, which are responsible for Alzheimer’s disease, bind to the folding protein Hsp90. The molecular recognition mechanisms that play a role here, have been unveiled by an international team of scientists led by the Technische Universitaet Muenchen (TUM) and the Helmholtz Zentrum Muenchen. This might open the door for new approaches for the treatment of Alzheimer’s disease.
When a cell is exposed to dangerous environmental conditions such as high temperatures or toxic substances, the cellular stress response, also called heat shock response, is initiated. Scientists could uncover an entire network of cellular helpers and thus identify new regulatory mechanisms of this stress response.
In biology, as in real estate, location matters. Working copies of active genes—called messenger RNAs or mRNAs—are positioned strategically throughout living tissues, and their location often helps regulate how cells and tissues grow and develop. But to analyze many mRNAs simultaneously, scientists have had to grind cells to a pulp, which left them no good way to pinpoint where those mRNAs sat within the cell.
Increasing the number of calories consumed by patients with amyotrophic lateral sclerosis (ALS) may be a relatively simple way of extending their survival. A phase 2 clinical trial led by Massachusetts General Hospital physicians found that ALS patients receiving a high-calorie, high-carbohydrate tube-feeding formula lived longer with fewer adverse events than participants who received a standard formula designed maintain their weight.
Nearly two months after Michael Schumacher suffered serious head injuries in a skiing accident and was placed in a drug-induced coma, some neurologists say the seven-time Formula One champion seems unlikely to make a full recovery. The 45-year-old Schumacher fell while skiing in France and hit...
For 15 years the trucks have barreled past southeastern New Mexico's potash mines and seemingly endless fields of oil rigs, hauling decades worth of plutonium-contaminated waste to what is supposed to be a safe and final resting place a half mile underground in the salt beds of the Permian Basin. ...
Utah's Republican governor announced Thursday he wants to reject a full Medicaid expansion that would enroll more people in the government program, and instead seek federal dollars to cover the poor in private plans. Gov. Gary Herbert's decision came after months of pushing back an announcement,...
In two new studies, the so-called “obesity hormone” leptin and hormones used for birth control are being examined for their potential role in the development of multiple sclerosis (MS).
Suited for researchers in the area of oncology, infectious disease, drug discovery, efficacy, and/or toxicology research, PerkinElmer’s IVIS Lumina series III integrates bioluminescence and full spectral fluorescence in vivo imaging technologies, providing an expandable and sensitive benchtop imaging system.
New research suggests that a protein only recently linked to cancer has a significant effect on the risk that breast cancer will spread, and that lowering the protein’s level in cell cultures and mice reduces chances for the disease to extend beyond the initial tumor.
Researchers report that one tiny variation in the sequence of a gene may cause some people to be more impaired by traumatic brain injury (TBI) than others with comparable wounds. The study measured general intelligence in a group of 156 Vietnam War veterans who suffered penetrating head injuries during the war. All of the study subjects had damage to the prefrontal cortex.
In the heart, as in the movies, 3D action beats the 2D experience hands down. In 3D, healthy hearts do their own version of the twist. Rather than a simple pumping action, they circulate blood as if they were wringing a towel. The bottom of the heart twists as it contracts in a counterclockwise direction while the top twists clockwise. Scientists call this the left ventricular twist—and it can be used as an indicator of heart health.
A team of scientists from UCLA's Jonsson Comprehensive Cancer Center has developed an experimental treatment that eradicates an acute type of leukemia in mice without any detectable toxic side effects. The drug works by blocking two important metabolic pathways that the leukemia cells need to grow and spread.
“Sprouted” garlic—old garlic bulbs with bright green shoots emerging from the cloves — is considered to be past its prime and usually ends up in the garbage can. But scientists are reporting that this type of garlic has even more heart-healthy antioxidant activity than its fresher counterparts.