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Wilex, Fox Chase Cancer Center to Turn Cancer Indicator into Possible Treatment 6/23/04

June 23, 2004 11:17 am | Articles | Comments

By Don Monroe A small-molecule treatment for breast cancer that targets the urokinase-type plasminogen activator (uPA) system has entered phase I clinical trials. The Fox Chase Cancer Center, Philadelphia

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Merck and Genetronics Shake Hands on Electroporation DNA Delivery Device 06/22/04

June 22, 2004 12:58 pm | Articles | Comments

By Catherine Shaffer Merck Co. Inc., Whitehouse Station, N.J., is gambling on an old technology to overcome obstacles in delivering new DNA vaccines. The global pharmaceutical company has recently signed an agreement with Genetronics Biomedical Corp., San Diego, to license their MedPulser DNA Delivery System, an electroporation device.

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Matrix Metalloproteinases

June 22, 2004 9:57 am | Articles | Comments

Matrix metalloproteinases (MMPs) are a group of Zn2+ dependent endopeptidases involved in remodeling and degradation of the extracellular membrane (ECM).

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Antioxidant Assay Kit

June 22, 2004 9:57 am | Articles | Comments

Antioxidant Assay measures the overall antioxidant capacity within a given sample. It relies on the ability of antioxidants in the sample to inhibit the oxidation of ABTS® in comparison to Trolox, a water-soluble tocopherol analogue.

Malachite Green Lipid Phosphatase Assay

June 22, 2004 9:57 am | Articles | Comments

Malachite Green Lipid Phosphatase assays offer a non-radioactive alternative for measuring specific phosphatase activities. Seven phosphatase substrates are available.

Instant ELISAs

June 22, 2004 9:57 am | Articles | Comments

Instant ELISA facilitates the quantitative detection of human TRANCE. TRANCE (or RANKL) is a member of the TNF superfamily that emerges as a key regulator of the immune system, of bone development, and of homeostasis.

Pre-Validated Kinase Sequencing Assays

June 22, 2004 9:57 am | Articles | Comments

An expanded SNP discovery service has been launched for pre-validated sequencing assays of kinases, genes implicated in many human diseases.

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Recombinant Proteins

June 22, 2004 9:57 am | Articles | Comments

Proprietary recombinant proteins are ideal for use as positive controls in a variety of applications, including in vitro transcription assays, as EMSA controls in DNA-protein interaction studies, and as protein standards in ELISAs and Westerns.

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Direct-Labeled Probe

June 22, 2004 9:57 am | Articles | Comments

New 450 kb probe detects alterations to the HER-2/ neu proto-oncogene (also called ERBB2), and is over-expressed in some breast, ovarian, prostate, and colorectal cancers, playing a possible role in tumor-cell proliferation, tumor invasion, and tumor metastasis.

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Immunology Research Catalog

June 22, 2004 9:57 am | Articles | Comments

Immunology line includes cytokine ELISA kits, cytokine ELISA construction kits, recombinant cytokines, growth factors, monoclonal and polyclonal antibodies, cytokines and CD markers, and matched antibody pairs. Custom immunological services are now available.

Caspases

June 22, 2004 9:57 am | Articles | Comments

Alexis Biochemicals offers over 240 enzymes, antibodies, inhibitors, assay kits, and other products for studying the role of caspases in apoptosis and inflammation.

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Adipogenesis Assay Kit

June 22, 2004 9:57 am | Articles | Comments

The Adipogenesis Assay Kit provides a convenient format for the induction and analysis of adipogenesis in the classic 3T3-L1 model. The most commonly used inducers of adipogenesis — dexamethasone, IBMX, and insulin — are provided in ready-to-use formulations.

HAT Activity Assay Kit

June 22, 2004 9:57 am | Articles | Comments

Histone acetyltransferases (HATs) play a crucial role in a variety of cellular functions such as gene transcription, differentiation, and proliferation. This HAT assay kit utilizes active recombinant HAT protein as a positive control and acetyl-CoA as a cofactor.

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Membrane Protein

June 22, 2004 9:57 am | Articles | Comments

Epidermal Growth Factor receptor (EGFr) 170 kDa membrane protein is expressed in many normal epithelial tissues, particularly in the basal layers of stratified or pseudostratified and squamous epitheliums.

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Bead-Based Assay Kits

June 22, 2004 9:57 am | Articles | Comments

LiquiChip™ bead-based xMAP™ assay kits facilitate research in drug discovery, cell signaling, oncogenesis, apoptosis, and immune disorders. Optimized immobilized substrates enable detection of a wide range of Tyr and Ser/Thr kinase activities without the need for radioactivity.

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