Bionas 2500 benchtop instrument simultaneously measures multiple metabolic parameters, including acidification, oxygen consumption and adhesion, in living cells, facilitating predictive pharmacology safety studies during preclinical phases of drug discovery. The label-free and non-invasive live cell-based assay employs sensor chips that replace the conventional bottom of culture wells. Various cell types including primary cells have been successfully tested. Readout is carried out continuously over long periods of time and can be watched online revealing a deep insight into cellular function. Regeneration effects can also be monitored. The system closely mimics the in vivo situation and aids compound selection during preclinical phases of drug discovery.