R&D Systems
614 McKinely Pl. NE
Minneapolis, MN, 55413
Website: http://www.RnDSystems.com
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Affinity Purified Monoclonal Antibodies
Anti-Oligodendrocyte Marker O1 and anti-Oligodendrocyte Marker O4 affinity purified monoclonal antibodies are now available. Oligodendrocytes are myelinating cells in the central nervous system (CNS) that form the myelin sheath of axons to support rapid nerve conduction. The monoclonal antibody O1 has been used in conjunction with the O4 antibody to define immature oligodendrocytes. The monoclonal antibody O1 reacts with a glycolipid antigen that is expressed on the surface of late oligodendrocyte progenitors, while the monoclonal antibody O4 reacts with an unidentified antigen. Progenitors that are O4 antigen-positive and O1 antigen-negative have been shown to differentiate into O1 antigen-positive oligodendrocytes in vitro.
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