BriteSpot microarray workstation standardizes and automates microarray hybridization, washing and drying in an ozone-safe environment. The quality of microarray data is enhanced by controlling human, physical and environmental factors that contribute to microarray data variability. Array throughput and reproducibility are increased. By automating and carefully controlling critical elements in the process, including hybridization and wash temperature, agitation, and exposure to ozone, users are able to minimize variation in data from non-biological sources.