Version 4.0 of PathwayStudio (formerly PathwayAssist, Ariadne Genomics, Inc.) contains new tools for microarray data analysis and pathway dynamics simulation, as well as over 1000 reconstructed pathways. It scales from desktop to enterprise-wide, and allows scientists to reconstruct pathways, understand biology from microarray/proteomics data, predict drug side effects and prioritize bio-markers in a complete, secure data management environment. Features and functionality include a pathway simulation module to explore the dynamic behavior of pathways and new tools for building relevance networks from gene expression data. MedScan Reader enables the viewing and automated extraction of scientific facts from biomedical literature, including MEDLINE abstracts, journal articles and other source references. PathwayStudio 4.0 comes with ResNet Core, a database of 50,000 validated facts and 1000+ reconstructed pathways, which can be extended to over 800,000 facts available in the ResNet 4.0 database. Ariadne Genomics, Inc.240-453-6296www.ariadnegenomics.com