TERANODE Screening Automation is an informatics package for screening laboratories with changing or emerging assay requirements. The package provides easy-to-deploy assay automation, flexible assay design and real-time analytics. Leveraging TERANODE XDA (the company’s Experiment Design Automation platform), the package consists of TERANODE Design Suite and the TERANODE Model Server with proven screening assay models. The Design Suite allows researchers to define screening assays, attach raw data files generated from the work, automate calculations of biological properties, annotate observations, and archive completed screening activities into a central repository. Once incorporated in the repository, the Model Server allows management and scientists to query or mine models and screening data to accelerate analysis and reporting. SOPs and screening records are shared, reviewed, and re-analyzed in "real-time" or years later. Training, development, and deployment times require a few weeks. Researchers are trained in the laboratory in hours. Advanced assay design by professional users is fast and database administration by IT professionals is minimal.