CloneFill (Genetix Ltd.) is a bench-top unit for filling 96, 24, 6 and single-well plates with cell-culture media. An optional stacker system extends the capacity of the stand-alone unit and integrates directly with both of the Genetix mammalian cell screening and picking systems, the ClonePix and ClonePixFL. Method set up takes less a minute and an entire 96 well plate is processed in around 15 seconds. A single manifold fits all plate types and easy-change flow paths allow a single fluid line to be dedicated to a specific media. All liquid contact parts can be sterilized by autoclave.