Peakfinder chemogenetic arrays are focused collections of drug-like molecules targeted towards specific receptor families and pre-optimized for robustness and bioavailability in man. They are designed to enhance receptor-ligand interactions within different but closely related families of targets, as previously exemplified by the Peakdale GPCR array. Based on predictive models, the compounds are front loaded with beneficial properties to provide a starting point for hit discovery resulting in fast, cost-effective lead optimization. The latest Peakdale array will be targeted toward protein kinases, a highly regulated family of enzymes that play a central role in most critical cellular processes.