Speedy 2002 is an automated system for solid phase extraction and filtration 96-well plate, cartridge or column format. With four independent probes, the system automatically conditions the separation material then dilutes and dispenses the samples. The samples are processed by applying vacuum and are collected in a receiving plate or eluent rack. For enhanced reproducibility the samples can be processed by applying controlled positive pressure with a user-defined, software-controlled flow rate. Filtration plates or cartridge racks are automatically exchanged.