Whole-genome DNA methylation arrays identify methylated regions in a high-throughput manner. The arrays can be used to correlate promoter and genic methylation with gene expression and/or phenotype and detect differential DNA methylation between normal tissues and tumor samples as potential diagnostic and prognostic markers. Arrays are available for human, mouse, rat, dog, and chicken genomes, tiling at an average probe spacing of 100 bp to provide an unbiased approach to DNA methylation analysis. These arrays survey not only regions surrounding known genes but also intergenic regions, allowing distal regulatory elements to be surveyed and providing opportunity to discover relevant biomarkers.
