Integrating Thermo Scientific’s QuickQuan software with the company’s Aria TLX System’s multiplexing technology allows quick assessment of thousands of new chemical entity samples in drug discovery research. QuickQuan software performs automated optimization of MS/MS parameters, enabling the rapid analysis of compounds. Analytical parameters can be sent to Aria software, which controls the TLX system, combining automated optimization with multiplexing to offer throughput for discovery applications such as: metabolic clearance, CACO2, PAMPA, protein binding and in-vivo PK. Data generated can be seamlessly transferred to the proprietary Galileo LIMS, enabling rapid data review and informed decision making.