Used with the ProteOn XPR36 system, the three ProteOn XPR36 sensor chips combine advanced surface chemistries with an alternate approach to surface chemistry activation to optimize ligand binding activity. Each of the chips can conduct up to 36 biomolecular assay interactions simultaneously in one experiment. They provide reliable and real-time measurement of multiple protein-protein, protein-peptide, protein-small molecule, and protein-DNA interactions. The three ProteOn system chips include: a GLC sensor chip for protein-protein interaction analysis; a GLM sensor chip for protein-small molecule applications; and an NLC sensor chip for immobilization of biotinylated proteins, peptides, and nucleic acids.