Guava Technologies, Inc.
25801 Industrial Blvd.
Hayward, CA, 94545
Website: http://www.guavatechnologies.com
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Early Measurement Of Cell Migration Response To Drugs
Using Guava Express™ assays and the Guava PCA cell analysis system, researchers can study cell migration and screen for drug compounds that affect that process. Guava collaborators at the Leiden University Medical Center in the Netherlands have shown that use of Guava Express in an actin polymerization assay can provide an early measure of chemotaxis (the migration of cells toward or away from a chemical stimulus), within seconds of exposure to stimuli. Cellular movement in response to chemical signals represents a fundamental property of immune cells because it enables their mobilization and deployment to sites of inflammation throughout the body. The process of chemotaxis can be measured at its initiation by assaying for actin polymerization within cells, a physiological requirement for cell movement. The actin assay can be readily adopted to identify drug compounds that enhance or inhibit chemotaxis or to study pathways involved in chemotaxis. The Express assay uses proprietary Guava Express software, a Guava PCA system and optimized Express secondary reagents. Broad dynamic provides the discrimination necessary for studying cell receptor up/down-regulation, screening transfectants, evaluating whole blood lymphocyte populations, and many other applications.
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