An improved method for isolating RNA from Formalin-Fixed Paraffin-Embedded (FFPE) samples of sufficient quality and quantity for microarray-based gene expression analysis is available. The method increases percent positive calls on high-density microarrays by reversing more of the cross-links introduced by the archiving process. The ArrayGrade FFPE RNA Isolation Kit and Service bring these profiling capabilities to even more areas of biological research including cancer and pathology.