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Gene Composer database and algorithm software for whole gene synthesis facilitates the rapid design of synthetic gene variants for improved protein expression and crystallization. Protein constructs can be defined based on crystal structures of homologous proteins, phylogenetic analyses, and protein structure prediction algorithms. Oligonucleotides can be designed for synthesizing the genes for the protein constructs. Factors which alter expression (codon usage, mRNA secondary structure, etc.) are incorporated into the gene design, which also improves protein expression. The software automatically extracts structural and sequence information from public or private resources and presents the information in its graphical interface. This information is distilled so researchers can quickly design re-engineered amino acid sequences, as well as the expression optimized synthetic nucleic acid gene sequences that encode the re-engineered proteins.© 2008 Advantage Business Media. All rights reserved.
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