PROMARK polymer detection kits for mouse and rat tissues offer biotin-free technology for immunohistochemistry (IHC), and provide sensitive staining and eliminates avidin-biotin blocking steps. A mouse-on-rat polymer kit has minimum cross-reactivity on rat tissues and is used with mouse primary antibodies on rat tissues. The mouse-on-mouse polymer kit was developed for use with mouse antibodies on mouse tissues. The rat-on-mouse polymer detection two-step kits are designed for using rat monoclonal antibodies on mouse tissues. Goat polymer detection kit (human, rat and mouse tissues) minimizes cross-reactivity to endogenous mouse and rat IgG.