MolSAR (Molecular Structure Activity Relationships) molecular modeling technology has been integrated into the KnowItAll Informatics System (Bio-Rad Laboratories, Informatics Group, Philadelphia, PA). MolSAR technology uses Bayesian neural network technology to build in silico models for a wide range of end points such as ADME/Tox properties or biological activities, allowing users to build their own predictive models using in-house experimental data and reference datasets pertaining to ligand moieties. The KnowItAll platform includes over 30 different pre-built models that can be used to predict properties such as water solubility, plasma protein binding, bio-availability, metabolism, mutagenicity and more. Using in-house or proprietary datasets, the MolSAR algorithm, integrated within the KnowItAll platform, will be able to be used to build, refine and/or optimize local models. The KnowItAll platform can also combine local and global models into a single framework, allowing expanded model usage across broader chemistries. Bio-Rad Laboratories, Inc.215-382-7800www.bio-rad.com