Bio-Rad Laboratories
Informatics Division
Two Penn Center Plaza
Suite 800, 1500 John F. Kennedy Blvd.
Philadelphia, PA, 19102
Website: http://www.knowitall.com
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ADME/Tox Databases
Thirteen databases have been introduced that contain measured ADME/Tox properties for a range of chemical compounds, covering seven endpoints including Blood Brain Barrier, Human Intestinal Absorption, log D, log P, Mutagenicity, Plasma-Protein Binding, and Water Solubility. Within drug discovery, most failed compounds have problems associated with their absorption, distribution, metabolism, excretion, or toxicity (ADME/Tox) profile. Virtual, or in silico ADME/Tox prediction is used to evaluate the profile of a compound, even before it is synthesized, in order to eliminate poor drug candidates early on in the drug discovery cycle.
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