ALTO-8 (ABgene Inc., Rochester, NY) automated capper/de-capper for ABgene Twist-Lock tubes, accesses eight sample tubes at a time. The system reduces the possibility of operator repetitive strain injury. Contamination is reduced both from the manual handling of caps, and for the first time on automated platforms, through the use of disposable pipette tips with capped tubes. As part of an automated, high throughput system, the ALTO-8 can be easily integrated with almost any new or existing robot set-up. It operates reliably in heavy and/or regular use. As a manual system, the compact and lightweight device (26 × 18 × 12 cm and under 4 kg) is user-friendly with an intuitive interface. An entire rack of screw-cap tubes can be processed, with pipetting, in less than ten minutes.