Applied BioPhysics, Inc.
185 Jordan Rd.
Troy, NY, 12182
Website: http://www.biophysics.com
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Signal Transduction Assay
ECIS™ (Electric Cell-Subtrate Impedance Sensing) method to detect morphological changes of cells in culture via impedance measurements can also be used to detect and monitor the activation of G-protein-coupled receptors. Studies of activation of both muscarinic and beta adrenegic receptors resulted in large reproducible impedance changes. These changes were blocked with the appropriate antagonist and the response studies returned proper EC50 values. As a whole-cell biosensor for drug discovery, this approach can be used to detect receptor activation and return information regarding the toxicity of test compounds.
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