Trimer-Tag technology takes advantage of the C-prodomains of collagen proteins, which are capable of efficient self-trimerization. Collagens are the most abundant and naturally occurring proteins secreted by mammals, including humans. This technology offers a new platform for the creation of trimeric soluble receptors and antibodies for more efficient targeting of corresponding disease-causing homotrimeric ligands, such as the TNF family of cytokines and HIV gp120.
