Clarity QSP system, for the purification of synthetic DNA/RNA, delivers nearly impurity free, concentrated, full-length oligonucleotide sequences. The system is offered in three cartridge formats and in 96-well plates. The cartridge formats are for applications that require increased loading capacities, purifying crude oligo samples in less than eight minutes using vacuum or positive pressure systems. The 96-well plate format can be easily automated for high-throughput parallel purification.