Beckman Coulter, Inc.
Biomedical Research
4300 N. Harbor Blvd.
Fullerton, CA, 92834
Website: http://www.beckmancoulter.com
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Genotoxicity Testing Kit
The gTox Flow Kit mouse micronuclei assay is used to evaluate the ability of a compound to cause chromosomal damage. It detects micronuclei formed from chromatin that are displaced as a result of chromosomal breakage. These nuclei are formed outside the main nucleus of the dividing cell. The assay enumerates micronucleated red cells in peripheral blood of treated mice. It is one of a battery of tests that chemical companies can use to comply with REACH (registration, evaluation, authorization and restriction of chemical substances) regulations in Europe. The kit, developed for the FC 500 Flow Cytometer (Beckman Coulter, Inc., Fullerton, CA) in both single- or dual-laser excitation configurations, incorporates a proprietary RBC permeation method and can be performed at room temperature without centrifugation preparation. The assay can be performed manually or automated on the Beckman Coulter Biomek NXP Laboratory Automation Workstation, and yields first results in less than two hours.
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