Beckman Coulter’s IOTest Anti-Cyclin A2 monoclonal antibody is offered for the study of cell cycle transitions in life science research. This FITC-conjugated antibody adds to the company’s universal cytometry reagent line, which works on all of their instrument platforms, including the Cell Lab Quanta and FC 500 MPL flow cytometers. Applications include basic research on cell cycle control, apoptosis and tumorigenesis; clinical cancer studies; and pharmaceutical discovery efforts to identify inhibitors, blockers and antimitotic drugs. The pre-formulated, standardized antibody is provided in 100-test vials. It is ready to use, adapted for permeabilization procedures such as cold methanol or IntraPrep with a wash, and may be used in multi-color applications with cell markers and DNA-content dyes such as 7-aminoactinomycin D (7-AAD) or propidium iodide.      Cyclin A2 is important in the transition to DNA synthesis and replication phases of the cell cycle and is abruptly destroyed as the cell moves into mitosis. Cyclin A2 is present in proliferating somatic cells, and its absence indicates that the cell is no longer replicating. The expression and diminishing expression of Cyclin A2 are thought to play a prominent role in tumorigenesis. Beckman Coulter, Inc. 800-742-2345 www.beckmancoulter.com