ProteomeLab Partitioning Systems and Chemistries provide advanced sample preparation for the isolation and analysis of protein-based biomarkers. The first product in this line is the ProteomeLab Igγ-12 Proteome Partitioning Chemistry. Based on avian-generated antibodies bound to inert beads, liquid chromatography and spin columns selectively partition the 12 most abundant proteins — up to 96% of the protein mass — from human serum or plasma. The enriched proteome, which includes medium- and low- abundant proteins, is the primary target for biomarker discovery. This material can then be collected and further fractionated with the ProteomeLab PF 2D System. Igγ chemistries offer clean capture and broad antigen-binding host range because of the evolutionary distance between chickens and mammals. The product is packaged in three formats: a high capacity LC column that can yield 3 to 5 mg of enriched proteome per day, a medium capacity LC column that can yield 0.6 to 1 mg per day and spin columns that can yield 0.3 to 0.5 mg per day. These products are available as complete solutions, including validated methodology, necessary reagents and instrumentation.