The open-architecture Arcturus^XT system is built upon the Nikon TE2000U inverted research grade microscope, and combines infrared (IR) laser-enabled laser capture microdissection (LCM) with ultraviolet (UV) laser cutting. The instrument is completely modular and can be fully upgraded, allowing utility to expand as requirements grow and microdissection technologies emerge. Automated image archiving enables sample custody to be maintained at all times. Optional high-intensity halogen illumination enables phase contrast and differential interference contrast application.