ImageXpressULTRA laser-scanning, confocal imager (Molecular Devices, Sunnyvale, CA) utilizes up to four configurable solid-state lasers and is available with a robotic plate handling option for automated, high throughput image-based screening. The system complements the ImageXpressMICRO wide-field CCD imager, both of which are controlled by MetaXpress Acquisition software and integrated into the modular image analysis and cellular Informatics software, AcuityXpress platforms. Over 15 application modules are available for MetaXpress for turnkey analysis of common HCS assays. AcuityXpress provides data mining and management tools as well as drill downs to the original high-resolution images. The confocal scanning instrument also complements the Transfluor GPCR image-based GPCR screening assay screening technology offered by Molecular Devices.