The miniDAWN TREOS multi-angle light-scattering (MALS) detector (Wyatt Technology) provides measurement of multi-angle light scattering (MALS) for small molecules. It has over twice the signal to noise ratio and 100× the dynamic range of the previous generation of miniDAWN instruments, allowing the measurement of smaller molecules at lower concentrations. Each analog signal (one for each of the three angles) is processed by instrument-based Digital Signal Processing (DSP) integrated circuit with 24-bit digital conversion. Four auxiliary analog inputs (with their own DSP circuits) are available for interfacing to external detectors, such as DRI, UV, PDA, etc. Optional features that can be added include the embedded COMET system, which automatically cleans the flow cell in situ.