The high abundance of globin mRNA in total RNA from whole blood substantially decreases the sensitivity of microarray experiments. GLOBINclear human globin mRNA removal kit employs removes >95% of globin mRNA from total RNA isolated from whole blood. The removal of globin mRNA in array analysis experiments results in an increase of as much as 17% of Percent Present calls, increased precision and lower 3'/5' ratios without affecting the relative expression profile.