Sigma-Aldrich has expanded its shRNA gene family sets in lentiviral format for direct use in gene silencing. MISSION TRC shRNA Human Kinases Gene Family is the second in a series of shRNA target sets that allows for rapid RNAi cell-based screens in mammalian systems not easily manipulated by traditional siRNA. The lentiviral transduction particle format eliminates the need to propagate bacterial cells, purify plasmid DNA or undertake the lengthy process of preparing virus, saving time and valuable resources. Lentiviral-based shRNA can be used to create a stable knockdown in almost any mammalian cell type, including primary and non-dividing cells. The MISSION TRC shRNA Human Kinases are also available as bacterial glycerol stocks. Additional gene family sets are available in both glycerol and lentiviral particle format.