Directed In Vivo Angiogenesis Assay (DIVAA) provides quantitative and reproducible results. DIVAA has been used in evaluating the inhibition of angiogenesis in matrix metalloprotease (MMP)-2-deficient mice and by TIMP-2 and enhancement of angiogenesis associated with adrenomedullin and CD97. The DIVAA Inhibition Kit was developed for screening inhibitors of angiogenesis; to this end, ample growth factor is provided for all 48 angioreactors.