Trevigen, Inc.
8405 Helgerman Court
Gaithersburg, MD, 20877
Website: http://www.trevigen.com
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3-D Culture Matrix For Cancer Research
3-D Cell Culture is an innovative approach to modeling the morphological effects of early oncogenesis in three-dimensional microenvironments. Healthy cells, undergoing differentiation, exhibit a structured, polarized morphology that is critical for cellular formation and function. During carcinoma development, cell cycle controls associated with cellular development, proliferation and death are lost, and as a result, these structures are disrupted. In effect, the morphology of these structures can be used as a measure to study factors in early carcinoma development. To aid in the advancement of this technology, Trevigen has developed Cultrex 3-D Culture Matrix RGF BME, a Basement Membrane Extract produced and qualified specifically for use in 3-D culture studies. The product provides the foundation for cells to grow in three dimensions allowing for the formation of structures in vitro. To provide the most standardized basement membrane extract for use in 3-D cultures, a process is employed to reduce growth factors and provide material at a standard concentration of approximately 14 mg/ml. Each lot of this material is then incorporated in a 3-D culture test to validate efficacy.
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