ÄKTAxpress MAb and HiTrap MabSelect SuRe provide high throughput, automated, multi-step purification of monoclonal antibodies. ÄKTAxpress MAb is a software modification to ÄKTAxpress — GE Healthcare’s modular system developed for high-throughput purification of protein samples. The system allows researchers to select single step affinity purification or two-step purification with an affinity first step, followed by desalting or gel filtration. The multi-step routines provide high purified targets with no cross-contamination between samples. HiTrap MabSelect SuRe is a column pre-packed with the new MabSelect SuRe base stable medium. The columns can be cleaned and re-used a number of times. When combined with the ÄKTAxpress MAb, researchers are able to reuse the MabSelect SuRe column utilizing pre-programmed cleaning in place (CIP) protocols.