From bright, high dynamic range applications to single photon imaging over long integrations, ImagEM CCD provides images with excellent signal-to-noise ratios. New methods for driving this CCD offer modes for fast, low noise operation, and provide synchronization with spinning disk confocal and multi-point confocal microscopes. With both on-chip multiplication and normal CCD readout amplifiers, a choice of readout speeds is included to match the signal-to-noise requirements of the application. On-board signal processing features provide a choice of real time frame averaging, background subtraction with offset and shading correction. Cooling and cooling stability provide quantitative data collection even at high frame rates.