Millipore Corporation
17 Cherry Hill Road
Danvers, MA, 01822
Website: http://www.millipore.com
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Phosphocellulose Filter Plates Optimize Kinase Assay Performance
MultiScreenHTS-PH 96-well filter plates for high throughput kinase screening assays. The 96-well filter plates are automation compatible and follow a prevalidated protocol. The filter plates incorporate PH paper for optimized kinase assay performance. PH paper retains peptide substrates to remove the unreacted, labeled ATP (Adenosine Triphosphate). PH paper provides low background and improves discrimination between drug target hits and non-hits. In addition, the paper is not subject to naturally fluorescent or quenching compounds. For this reason, the plates are especially compatible with aromatic-based libraries. Kinase assays are a critical step in both lead identification and later lead characterization processes. Filter-based tools are a proven method for kinase assays and in-plate radiometric analysis. The MultiScreen protocol eliminates the need to design, develop, and optimize various combinations of reagents.
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