IntelliFlash 280 fully automated flash chromatography system is compact enough to fit within tight flume hoods, and minimize set-up time and maximizes purification results by integrating a pump, column, detector, collector and controls. The control system has a built-in computer with touch screen. IntelliPeak software, a Windows-based wizard, provides a flexible programming template for method development, execution, and archiving. Flexible peak detection algorithms enhance separation results. The UV detector (254 nm standard) has a wide dynamic range (0 – 4.0000AU) and low baseline noise. Configurable fraction collection options include high capacity tube, bottle and funnel collection racks. Interchangeable Unimount column cartridge holder options hold industry standard “F-Series” cartridges and Direct Luer Connect cartridges containing 4-330g of flash silica.