Chemical Inkjet Printer (ChIP) offers a new approach to Peptide Mass Fingerprinting (PMF) and Protein Macroarray Analysis. ChIP is a unique technology platform for micro-scale on-membrane protein identification and characterization with widespread applications in biomedical and diagnostic discovery. Nanotechnology fluidics enable microprinting to be carried out on just a fraction of a protein spot. This allows further study on the remainder of bioactive materials. ChIP's piezoelectric 'drop-on-demand' ink-jet technology allows for the precise delivery of picoliter volumes of reagents to defined locations on a PVDF membrane. The system can deliver up to four different chemistries to the same spot, allowing for multiple enzyme digests on one spot and thereby increasing sequence coverage of a protein. Proteomics researchers no longer have to carry out in-gel digestion, peptide extraction and C18 clean-up steps. The technology can also be used to dispense multiple antibodies to screen for antigens in minutes rather than hours, transforming Western blotting protocols into rapid, quantitative and automated techniques.