Piezorray non-contact microdispensing system is designed specifically for pipetting sub-nanoliter volumes to dense arrays. Liquid volumes are controlled by a piezoelectric tip that dispenses reproducible picoliter volume droplets. The instrument is able to pipette into and aspirate out of a number of standard plate formats, and dispense to a variety of porous and non-porous substrates for creating arrays, and is controlled by an external computer. The base unit contains one source plate holder, an ultrasonic washbowl, a computer and a monitor, and a bottle for system liquid.