HPLC software system ASTRA V from Wyatt Technology compliments the company’s multi-angle light scattering detectors for absolute molecular weight determinations. ASTRA V can be used for both on-line HPLC measurements and off-line batch measurements. Supported applications include: data collection and analysis for absolute molecular weight and size determination from the Wyatt’s DAWN EOS and miniDAWN Tristar MALS instruments; QELS data collection and analysis from the WyattQELS (Quasi Elastic Light Scattering) instrument; concentration measurements from the Optilab rEX and other refractometers; determination of intrinsic viscosity from the Wyatt ViscoStar, differential viscometer; and the ability to correct for band-broadening (sample dispersion/spreading) for an unlimited number of instruments. The updated package includes networked instrument communication, database storage, 21 CFR Part 11 compliance and new collection paradigms such as completely configurable sample sets and support for high throughput experiments. New analysis capabilities such as proprietary band broadening corrections, absolute number density determinations, and global fitting for online and batch Zimm plots unlock insights into sample data that have never been seen before.