This system is designed for manual post-extraction clean-up of interfering substances from environmental samples and animal tissue by gel permeation chromatography (GPC) prior to analysis by GC, GC/MS, HPLC or LC/MS. To improve analytical results, lengthen hardware life and increase analytical systems uptime, the system removes the interfering compounds after sample extraction and prior to analysis. It is simple and useful in labs with limited bench space, a short-term GPC clean-up project or a low number of samples to purify per month.