LEADseeker™ Multimodality Imaging System from Amersham Biosciences has added fluorescence polarization, time resolved fluorescence (TRF), and TR-FRET capabilities to an instrument that offers radiometric, luminescence, and fluorescence resonance energy transfer (FRET) detection. CCD (charge coupled device) detection technology combines with powerful data processing and analysis to allow testing of more than one million drug compounds in a single day. LEADseeker detects light emitted from an entire microtiter plate at one time, regardless of the number of wells. A rapid plate transfer system, sophisticated optics, and high-speed data processing capabilities enable the instrument to process an entire microtiter plate in less than 20 seconds.