The low noise two-channel wireless data acquisition system, RatPaak, is used to monitor physiological parameters, including electroencephalogram (EEG), electromyogram (EMG), electrocardiogram (ECG), electrooculogram (EOG) or Polysomnography (PSG) in small laboratory animals that weigh 100 grams or more. The system consists of a compact integrated transmitter with a form factor that can be used on rats and other small animals. The device includes an analog to digital (A/D) converter, miniature MicroSynth RF radio transmitter and a microprocessor. It weighs about 1/4 oz. and can transmit signals to a nearby receiver up 50 ft away. The receiver, which is connected to the serial port of a personal computer, provides real-time viewing of signal data. Data can be viewed using BioCapture software and simultaneously saved to the PC hard drive. ASCII conversion tools can be utilized to provide data analysis in software packages, such as MATLAB, LabVIEW and Excel.