Polyplus-transfection has developed a new class of cationic oligonucleotides called ZNA. The company has recently established proof of concept showing that ZNA used as detection probes improve PCR technology performance. In particular, ZNA increase the sensitivity of tests and the ability to detect mutations. The products offers an increased affinity for nucleic acids without losing selectivity and therefore will improve the performance of other molecular hybridization techniques such as
in situ hybridization and microarrays. They could also be used for
in vitro detection of micro-RNAs, a new class of intracellular effectors.
Polyplus-transfection, +33 (0)3 90 40 61 80, www.polyplus-transfection.com