FibraStage eliminates autoclaving, cleaning, lengthy learning curves, costly start-up, and cross-contamination issues between batches. In place of dozens of roller bottles or hundreds of T-flasks, the high-yield system can produce mg quantities of proteins, virus or cell mass using just one to four, disposable 500 mL bottles. Each bottle comes pre-filled with FibraCel disks, a solid support matrix that provides a high-surface area and low-shear environment for cell growth.