Synergy 4 multi-mode reader combines filter-based and quadruple monochromator-based fluorescence detection technology to perform an unlimited number of microplate-based assays. This Hybrid Technology provides for flexibility in current and future microplate-based assay choice. In addition, Synergy 4 includes fluorescence intensity, luminescence, fluorescence polarization, time-resolved fluorescence, and UV-visible absorbance. Filter-based fluorescence technology provides optimal light filtering and purification for sensitivity. Filter system design provides fast wavelength switching and high read speeds.