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Cooperation Between Industry, FDA Leads to Rebound in Drug Innovation 2/10/04

February 10, 2004 10:53 am | Articles | Comments

by Don Monroe, PhD The US Food and Drug Administration reported in January what it called a rebound in approval of innovative drugs in 2003.

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Fluorescent Screening For Kinase, Phosphatase Inhibitors

February 10, 2004 6:57 am | Articles | Comments

The Z'-LYTE™ assay platform (Invitrogen Corp.) provides a fluorescence-based biochemical

Untouched B Cell Isolation

February 10, 2004 6:57 am | Articles | Comments

Miltenyi Biotec has announced the release of several new MACS® products for the isolation of untouched human B cells.

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Anti-human TCR Antibodies

February 10, 2004 6:57 am | Articles | Comments

Anti-human TCR V?12.1 monoclonal antibody is for validated applications including flow cytometry, immunoprecipitation, frozen tissue staining, and T cell activation. Anti-human TCR V?6.

Phospho-ERK2 ELISA

February 10, 2004 6:57 am | Articles | Comments

Phospho-ERK1/ERK2 DuoSet® IC ELISA Development System kits (R&D Systems) provide an alternative to Western blots for intracellular factors involved in signal transduction, apoptosis, and transcription.

Characterize, Quantify IgG Purity And Heterogeneity

February 10, 2004 6:57 am | Articles | Comments

ProteomeLab™ IgG purity/heterogeneity assay (Beckman Coulter) is offered in kit format with a validated standard operating protocol (SOP).

Chemiluminescent Substrate (2747)

February 10, 2004 6:57 am | Articles | Comments

BioFX's chemiluminescent substrates are used in immunoassay and immunoblotting applications. The reagents are intensified and the signal duration increased by proprietary enhancers.

HDAC8 Activity Assay

February 10, 2004 6:57 am | Articles | Comments

HDAC8 Colorimetric/Fluorometric Activity Assay/Drug Discovery Kit is HTS-friendly assay and allows real-time monitoring of HDAC activity. This is made possible by HDAC-TRAC™ substrate and buffer, which also enables a choice of either colorimetric or fluorometric detection.

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HSP27 (Heat Shock Protein) ELISA

February 10, 2004 6:57 am | Articles | Comments

HSP27 [pS82] phosphoELISA™ is sensitive to 1,000 cells/well, demonstrated with HeLa cell lysates. Additional validated cell lines include THP-1, HT1080, Jurkat and 293 cells.

TAFI (Thrombin Activatable Fibrinolysis Inhibitor) Assay

February 10, 2004 6:57 am | Articles | Comments

Pefakit® TAFI is a highly specific, 2-step chromogenic assay for the measurement of TAFI (Thrombin Activatable Fibrinolysis Inhibitor) in plasma.

Inhibin B ELISA

February 10, 2004 6:57 am | Articles | Comments

Diagnostic Systems Laboratories, Inc. has launched an Inhibin B ELISA. It is specific for dimeric Inhibin B, does not require sample pretreatment, and can be fully automated on open-platform microplate systems.

Mouse Anti-c-Kit Monoclonal

February 10, 2004 6:57 am | Articles | Comments

The c-Kit proto-oncogene encodes a 145-165 kDa transmembrane receptor (CD117) with tyrosine kinase activity that is structurally related to platelet-derived growth factor. In normal tissues, monoclonal 2E4 stained mast cells and intestinal Cajal cells.

Marker For Degenerating Neurons

February 10, 2004 6:57 am | Articles | Comments

Fluoro-Jade® B is a polyanionic fluorescein derivative that sensitively and specifically binds to degenerating neurons. It is a dark red powder that has a green iridescence with excitation peak at 480 nm and emission peak at 525 nm.

Co-Stimulatory Molecule ELISA

February 10, 2004 6:57 am | Articles | Comments

New series of ELISAs and Instant ELISA kits is offered for the detection of soluble co-stimulatory molecules. The products are useful for research into how manipulation of of the co-stimulatory signals enhance or terminate immune responses.

DNA/RNA Oxidative Damage Markers

February 10, 2004 6:57 am | Articles | Comments

Murine Monoclonal Antibody recognizes 8-hydroxy-deoxyguanosine, 8-hydroxy-guanine and 8-hydroxy-guanosine. The antibody can be used in ELISA and immunohistochemistry to detect these markers of oxidative damage to DNA and RNA.

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